Microsoft's Ironpython?
I've noticed a recent post in a blog from http://www.johndcook.com/blog/category/python/
Sho is an interactive environment for data analysis and scientific computing that lets you seamlessly connect scripts (in IronPython) with compiled code (in .NET) to enable fast and flexible prototyping. The environment includes powerful and efficient libraries for linear algebra as well as data visualization that can be used from any .NET language, as well as a feature-rich interactive shell for rapid development.
http://blogs.msdn.com/b/the_blog_of_sho/archive/2011/01/26/introducing-sho.aspx
See also http://www.johndcook.com/blog/2010/07/01/scipy-and-numpy-for-net/
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